Porous scaffolds for biomedical applications

Porous scaffolds for biomedical applications


Implantable biomaterials are often designed in the form of porous templates (scaffolds) to allow tissue regeneration, ingrowth and remodeling in 3D. We are developing bioactive glass-based scaffolds with controlled porosity by making use of different fabrication methods. Combination of sol-gel process with foaming strategies followed by sintering allowed the production of hierarchical bioactive glass scaffolds with multiscale porosity from the macro- to the meso-range. Basic glass compositions were also doped with small amounts of metallic cations that can be exploited to perform a local therapeutic action. In this regard, magnetite-containing glass-ceramic scaffolds were obtained by doping a silicate glass with iron and by then carefully selecting the sintering conditions; as a result, these porous devices can potentially elicit a mu.jpgunctional action including treatment of osseous tumors via hyperthermia and bone regeneration at the resected bone site. In the framework of a collaboration with Dr. Jonathan Massera (Technical University of Tampere, Finland ), we are also investigating the potential of additive manufacturing to produce bioactive glass scaffolds with highly-ordered 3D macroporous architecture.


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Recent reference(s)

M. Miola et al., Int J Appl Glass Sci 7 (2016) 238-247

F. Baino et al., Acta Biomater 42 (2016) 18-32

F. Baino et al., Int J Appl Ceram Technol 14 (2017) 507-520

F. Baino et al., Materials 11 (2018) 173

M. Yu et al., Mater Lett 232 (2018) 14-17