Bioactive glass particles as filler for the development of composite electrospun fibers

Title

Bioactive glass particles as filler for the development of composite electrospun fibers

Description

Bioactive glasses have been deeply investigated for their versatility, tailorable degradability, surface reactivity and ability to interact with tissues and cells. In particular, bioactive glass nanoparticles have attracted the attention of the researcher due to their unique properties such as specific surface area. Bioactive glass nanoparticles can be incorporated in different matrices and represent a very promising material for tissue regeneration. We have designed and synthesized via sol-gel method submicron bioactive glass particles containing ions with therapeutic effect (e.g. Cu, B). The obtained nanoparticles have been characterized in terms of morphology, composition, structure and reactivity in simulated body fluid. Subsequently, bioactive glass particles have been embedded in different polymeric fibers obtained by eletrospinning (e.g. PCL, ) in collaboration with Prof. D. Pisignano (Università di Pisa) and Prof. A.R. Boccaccini (University of Erlangen-Nuremberg) to develop composite electrospun fibers for hard and soft tissue regeneration.

Picture(s)

Figure: a) bioactive glass nanoparticles, b) hydroxyapatite precipitated on bioactive glass nanoparticles/PCL fibers

Keywords

Bioactive glass particles; ion release; electrospinning; composite fibers; tissue engineering

Contact(s)

Marta Miola: marta.miola@polito.it; Enrica Vernè: enrica.verne@polito.it.

Recent reference(s)

F. Serio, M. Miola, E. Vernè, D. Pisignano, A.R. Boccaccini, L. Liverani. Electrospun Filaments Embedding Bioactive Glass Particles with Ion Release and Enhanced Mineralization. Nanomaterials 2019, 9, 182.