Anti-adhesive and-inflammatory coating for non-permanent implants or devices fibers
Anti-adhesive and-inflammatory coating for non-permanent implants or devices
Description: An anti-adhesive coating could be important for all applications involving temporary implants and requiring poor cell adhesion, to prevent tissue integration, such as in the case of temporary orthopaedic implants, which could create difficulties once the implant is in the removal phase, contact lenses, catheters, and voice prostheses. The intended coating is also antibacterial and anti-inflammatory, with the goal of preventing implant-associated infection and modulating inflammatory response. Vitamin E appears to be a good candidate to create a hydrophobic coating, which provides poor adhesion for both cells and bacteria, as well as redox and radical scavenging properties. As an example, the substrate used is a titanium alloy (Ti6Al4V) which undergoes a surface treatment, making it microporous and with roughness at the nanoscale, with acidic OH groups exposed on the surface useful to ensure adhesion of the coating on the substrate.
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Keywords
Biomaterials, Titanium, Vitamin E, Temporary Implant.
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Funding
BeBoP: Functionalization of implantable biomaterials with biomolecules of plant origin: from surface engineering to biological response. Joint research Project (PhD)