Surface functionalization of biomaterials
Description
Interaction between biomaterials and biological environment plays mainly at the interface. Surface modification of biomaterials with molecules able to modulate biological response through physiological healing is a promising strategy for improvement of implants performances. In this context, specific protocols have been developed in order to expose and activate reactive functional groups (mainly OH groups) on the surface of bioactive glasses and Ti alloys (modified to be bioactive) suitable for grafting of biomolecules . Different molecules have been explored (e.g. amino-silanes, alkaline phosphatase, gallic acid and natural polyphenols). Actually, this research is mainly focused on natural molecules of vegetal origin (polyphenols extracted from natural sources, essential oils, glyceric macerates) in order to favour a sustainable use of resources. The presence and activity of the grafted molecules has been verified on the modified surfaces as well as their biological response. The opportunity to exploit the reducing ability of grafted polyphenols for in situ reduction of antibacterial metallic nanoparticles has also been explored.
Contact(s)
Recent reference(s)
M. Cazzola et al. J Mater Sci (2017)
S. Ferraris et al. Appl. Surf Sci 396(2017)461-470
M. Cazzola et al Appl. Surf Sci 367(2016)237-248
I. Corazzari et al. Coll. Surf. B 148(2016)592-599
S. Ferraris et al J Non-Cryst Solids 432(2016)167-175
X. Zhang et al. Appl. Surf. Sci. 287(2013) 341-348
X. Zhang et al. Appl. Surf Sci 287(2013)329-340
Funding:
NAT4MORE: NATural molecules on the surface of bioactive materials FOR MOdulating the host REsponse to implants, M-ERANET call 2016
BeBoP: Functionalization of implantable biomaterials with biomolecules of plant origin: from surface engineering to biological response. Joint research Project (PhD)
Grants 2016 and 2017 from Geal Pharma